Dangerous Drugs

Avandia Linked to Heart Failure and Stroke

This Alert Affects:

Non-smoking individuals with Type 2 Diabetes who were prescribed Avandia and suffered serious health complications, such as heart attack, stroke, or heart failure, may have legal recourse. Family members of individuals who have died because of Avandia side effects may also be eligible to recover compensation for their loss.

Damages
Avandia has been linked to congestive heart failure, heart damage, heart attack, hemorrhagic stroke, ischemic stroke, macular edema, and sudden cardiac death. Bone fractures have also been reported in females.
Company(ies)
GlaxoSmithKline
Additional Details
Avandia was introduced in 1999 and was designed to be a safer alternative to drugs that were previously available. It is prescribed to diabetes patients as part of a treatment program for type 2 diabetics that includes diet restrictions and a regular exercise.
Date
This product has not been recalled, but the FDA issued a safety warning for Avandia in May 2007. Furthermore, in September 2010, the FDA placed strict restrictions on Avandia, making it a drug of last resort for diabetes patients.

Avandia (Rosiglitazone) is a prescription medication used to treat type two diabetes. It works by aiding the body's natural use of insulin, thereby lowering blood sugar. It was originally developed in 1999 and has been used by more than four million diabetes patients. In recent years, Avandia has been linked with dangerous side effetcs including an increase in the risk of heart attack (myocardial infarction).

In 2001, the Food and Drug Administration (FDA) asked manufacturer GlaxoSmithKline to stop providing information which minimized the alleged risks associated with Avandia use. The following year the FDA informed doctors of additions to the warning label which pointed out the possibility of excess fluid retention and congestive heart failure. Later, in 2002, the FDA again request a change in the Avandia warning material to reflect reports of unusual weight increases associated with use of the drug. Three changes to the warning label were requested by the FDA in 2007 all of which indicated the risk of heart problems resulting from use of the drug, including myocardial ischemia and heart failure.

Other dangerous side effects include:

  • Stroke
  • Liver toxicity
  • Primary pulmonary hypertension
  • Increased cholesterol levels

FDA Restrictions

In September 2010, the FDA placed strict restrictions on Avandia, which research suggests increases the risk of heart attack and other cardiovascular problems. According to the new guidelines, patients will only be prescribed Avandia after every other diabetes drug has been tried, and they are fully aware of the cardiovascular side effects of the drug. Furthermore, due to the serious side effects of Avandia, the FDA announced in 2008 that it would no longer approve drugs just because they help diabetes patients control their blood sugar levels. Rather, the FDA now requires that drug manufacturers conduct at least two years of drug trials to ensure their products do not cause any damage to the heart and they help improve the quality or length of life for diabetics.

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